Author

E. Chuang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Shorter· 5 shared R. R. Cupo· 3 shared D. R. Southworth· 2 shared H. Kim· 2 shared J. Lin· 2 shared K. L. Mack· 2 shared X. Yan· 2 shared A. JoachimiakiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersBiochemistry

J. Shorter

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Design principles to tailor Hsp104 therapeutics

J. Lin, P. J. Carman, C. W. Gambogi, N. M. Kendsersky, E. Chuang, S. N. Gates, A. L. Yokom, A. N. Rizo, D. R. Southworth, J. Shorter

This paper identifies design principles for modifying Hsp104 to enhance its therapeutic potential by tuning its collaboration with Hsp70 and Hsp40.

bioRxiv · Apr 26, 2024Bioengineering

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

E. Chuang, R. R. Cupo, J. R. Bevan, M. L. Rice, S. Mao, E. L. Gorenberg, K. L. Mack, D. M. Huryn, P. Wipf, J. L. Brodsky, J. Shorter

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

bioRxiv · Jan 11, 2024 · PreprintBiochemistry

Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.

R. R. Cupo, A. Rizo, G. A. Braun, E. Tse, E. Chuang, D. R. Southworth, J. Shorter

The paper reports the structure of Skd3-substrate complex, revealing its dodecamer formation and mechanism of protein disaggregation, with implications for SCN and MGCA7.

bioRxiv · Feb 17, 2022Biochemistry

Tuning Hsp104 specificity to selectively detoxify alpha-synuclein

K. L. Mack, H. Kim, M. E. Jackrel, J. Lin, J. E. DeNizio, X. Yan, E. Chuang, A. Tariq, R. R. Cupo, L. M. Castellano, K. A. Caldwell, G. A. Caldwell, J. Shorter

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

bioRxiv · Apr 15, 2020Bioengineering

Therapeutic genetic variation revealed in diverse Hsp104 homologs

Z. March, K. Sweeney, H. Kim, X. Yan, L. Castellano, M. Jackrel, E. Chuang, E. Gomes, K. Michalska, R. Jedrzejczak, A. Joachimiak, K. Caldwell, G. Caldwell, O. Shalem, J. Shorter

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

bioRxiv · Mar 25, 2020Biochemistry