Author

R. R. Cupo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Shorter· 3 shared E. Chuang· 2 shared A. Rizo· 1 shared A. Tariq· 1 shared D. R. Southworth· 1 shared E. Tse· 1 shared G. A. Braun· 1 shared G. A. Caldwell· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

J. Shorter

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivFeb 17, 2022

Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3.

R. R. Cupo, A. Rizo, G. A. Braun…·J. Shorter

The paper reports the structure of Skd3-substrate complex, revealing its dodecamer formation and mechanism of protein disaggregation, with implications for SCN and MGCA7.

DOI 10.1016/j.celrep.2022.111408

humanstructural biology

𝕏 PostBluesky

BioengineeringbioRxivApr 15, 2020

Tuning Hsp104 specificity to selectively detoxify alpha-synuclein

K. L. Mack, H. Kim, M. E. Jackrel…·J. Shorter

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

DOI 10.1016/j.molcel.2023.07.029

C. elegansprotein structure

𝕏 PostBluesky

BiochemistrybioRxivJan 17, 2020

Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

R. R. Cupo, J. Shorter

This study identifies Skd3 (human CLPB) as a mitochondrial protein disaggregase inactivated by mutations causing 3-methylglutaconic aciduria.

DOI 10.7554/elife.55279

humanproteomics

𝕏 PostBluesky