G. Balazsi

The paper identifies transcriptional drift in aging C. elegans worms, showing upregulated sensory proteins and downregulated growth/metabolism genes, and proposes a mechanistic model involving ligand binding.

The paper identifies a luminal intermediate cell state in the prostate that maintains homeostasis and contributes to tumorigenesis in mouse models, with potential relevance to human prostate cancer.

The paper identifies therapeutic targets and novel metastasis regulators by analyzing gene expression heterogeneity in triple-negative breast cancer using single-cell RNA sequencing.

The paper models the evolutionary dynamics of lysogens and nonlysogens to show there is an optimal spontaneous prophage induction rate that benefits lysogens.