F. Luo

Micropolarity governs the structural organization of biomolecular condensates

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesis

The paper identifies a luminal intermediate cell state in the prostate that maintains homeostasis and contributes to tumorigenesis in mouse models, with potential relevance to human prostate cancer.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Candidatus Nealsonbacteria (OD1) are biomass recycling ectosymbionts of methanogenic archaea in a stable benzene-degrading enrichment culture

The paper identifies Ca. Nealsonbacteria DGGOD1a as a biomass recycling ectosymbiont of methanogenic archaea in a benzene-degrading consortium.

Transient Oxygen Exposure Causes Profound and Lasting Changes to a Benzene-Degrading Methanogenic Community

Transient oxygen exposure inhibited methanogenic benzene degradation for a year, causing decay of benzene-fermenting bacteria in an anaerobic culture.

Editing the CsDMR6 Gene in Citrus Results in Resistance to the Bacterial Disease Citrus Canker

This study edits the CsDMR6 gene in citrus to confer resistance to citrus canker, showing significant reduction in disease symptoms and bacterial population.

A chromosome-level phased Citrus sinensis genome facilitates understanding Huanglongbing tolerance mechanisms at the allelic level in an irradiation induced mutant

The paper presents a chromosome-level phased genome of Valencia sweet orange, enabling allelic-level analysis of Huanglongbing tolerance in mutants.

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

A Phytochrome B-PIF4-MYC2 Module Tunes Secondary Cell Wall Thickening in Response to Shaded Lighting

The paper identifies a PHYB-PIF4-MYC2 module that regulates secondary cell wall thickening in Arabidopsis under shaded light conditions.

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway

This study shows olanzapine induces NAFLD via the apoA5 pathway by increasing hepatic apoA5 protein and sortilin levels, with APOA5 knockdown reversing steatosis.

Anaerobic Benzene Biodegradation Linked to Growth of Highly Specific Bacterial Clades

This study compares bioremediation approaches for anaerobic benzene degradation, finding that nitrate amendment or methanogenic bioaugmentation enhance degradation while sulfate biostimulation does not.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion

This study shows that lung-stage schistosome infection reduces allergic airway inflammation by increasing allergen-specific Treg cells that inhibit IgE and Th2 cytokine production.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules

This paper develops a method to use conventional electron microscopes for high-resolution structure determination of small molecules and macromolecules by synchronizing the stage and camera.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.