Reconstructing cell interactions and state trajectories in pancreatic cancer stromal tumoroids
R. Okuda, B. Gjeta, D. Popovic, A. Manyard, Q. Yu, Z. He, M. Santel, M. Seimiya, S. Morinaga, Y. Miyagi, T. Yamaguchi, Y. Ueno, H. Taniguchi, B. Treutlein, G. Camp
This study develops a stromal tumoroid model of pancreatic cancer to investigate cell interactions and state changes, identifying key factors like SDC1 and PPARG that influence cancer cell behavior and therapy response.
bioRxiv · Feb 14, 2022 · PreprintCancer Biology