Author

B. Treutlein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Evolutionary Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Organism:human· 6 Assay:scRNA-seq· 6 Approach:experimental assay· 5 Research Focus:clustering· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3

Frequent Co-Authors

M. Santel· 4 shared G. Camp· 3 shared J. G. Camp· 3 shared Q. Yu· 3 shared A. Weigert· 2 shared J. R. Spence· 2 shared M. Seimiya· 2 shared U. Kilik· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBioengineering

M. Santel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts

H.-C. Lin, J. Janssens, A.-S. Kroell, P. Hornauer, M. Santel, R. Okamoto, K. Karava, M. Priouret, M. P. Garcia, M. Schroeter, J. G. Camp, B. Treutlein

The paper programs human neuron subtypes using combinatorial patterning and scRNA-seq to identify diverse neuron types and their developmental signaling networks.

bioRxiv · Dec 12, 2023 · PreprintBioengineering

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Q. Xu, L. Halle, S. Hediyeh-zadeh, M. Kuijs, U. Kilik, Q. Yu, T. Frum, L. Adam, S. Parikh, M. Gander, R. Kfuri-Rubens, D. Klein, Z. He, J. S. Fleck, K. Oost, , J. G. Camp

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

bioRxiv · Nov 20, 2023Cell Biology

Reconstructing cell interactions and state trajectories in pancreatic cancer stromal tumoroids

R. Okuda, B. Gjeta, D. Popovic, A. Manyard, Q. Yu, Z. He, M. Santel, M. Seimiya, S. Morinaga, Y. Miyagi, T. Yamaguchi, Y. Ueno, H. Taniguchi, B. Treutlein, G. Camp

This study develops a stromal tumoroid model of pancreatic cancer to investigate cell interactions and state changes, identifying key factors like SDC1 and PPARG that influence cancer cell behavior and therapy response.

bioRxiv · Feb 14, 2022 · PreprintCancer Biology

Maturation of human intestinal epithelium from pluripotency in vitro

U. Kilik, Q. Yu, R. Holtackers, M. Seimiya, A. Xavier da Silveira dos Santos, B. Treutlein, J. R. Spence, G. Camp

This study develops an in vitro protocol to generate mature human intestinal epithelium from pluripotent stem cells using NRG1 and single-cell transcriptomics.

bioRxiv · Sep 24, 2021 · PreprintCell Biology

Nuclei are mobile processors enabling specialization in a gigantic single-celled syncytium

T. Gerber, C. Loureiro, N. Schramma, S. Chen, A. Jain, A. Weber, A. Weigert, M. Santel, K. Alim, B. Treutlein, J. G. Camp

This study investigates gene expression heterogeneity in the multinucleated slime mold Physarum polycephalum, showing region-specific transcriptional responses and nuclear specialization without cellular compartmentalization.

bioRxiv · Apr 29, 2021Cell Biology

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

M. Schoernig, X. Ju, L. Fast, A. Weigert, T. Schaffer, S. Ebert, B. Treutlein, N. Nadif Kasri, B. Peter, W. Hevers, E. Taverna

This study compares the maturation of induced neurons from chimpanzee, bonobo, and human stem cells, finding slower structural and functional development in humans.

bioRxiv · May 21, 2020Evolutionary Biology

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

E. Khrameeva, I. Kurochkin, D. Han, P. Guijarro, S. Kanton, M. Santel, Z. Qian, S. Rong, P. Mazin, M. Bulat, O. Efimova, A. Tkachev, S. Guo, C. Sherwood, G. Camp, , P. Khaitovich

The paper identifies gene expression differences between human and non-human primate brains at single-cell resolution, revealing rapid evolution in specific cell types.

bioRxiv · Sep 10, 2019Evolutionary Biology