D. Han

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

RFC1 AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVAS

The paper identifies and structures the G-quadruplex formed by RFC1 AAGGG repeats, showing its role in replication stalling and transcription inhibition in CANVAS.

How formate dehydrogenase-lacking acetogen Clostridium bovifaecis utilize formate as the sole carbon source for its acetogenic growth?

This study investigates how Clostridium bovifaecis, an FDH-lacking acetogen, uses formate as the sole carbon source for acetogenesis by converting it to acetate with a 2.0:1 to 2.6:1 molar ratio.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

Unannotated small RNA clusters in circulating extracellular vesicles detect early stage liver cancer

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.

ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation

This paper presents an in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by screening compounds that suppress crystal formation in C. elegans.

Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission

The paper shows that centrosome-nucleated biomolecular condensates of the Destruction Complex enhance β-catenin degradation and regulate Wnt signaling in human embryonic stem cells.

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

The paper identifies replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND and mass spectrometry, finding BRWD3 promotes fork progression and genome stability.

Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

This study shows that extracellular vesicles from highly glycolytic breast cancer cells induce an aggressive phenotype in low glycolytic luminal breast cancer cells via PKM2 phosphorylation.

Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

Antibiotic-dependent relationships between nasal microbiome and secreted proteome in chronic rhinosinusitis and nasal polyps

This study examines how antibiotic use affects the nasal microbiome and secreted proteome in chronic rhinosinusitis, finding that antibiotics alter their associations.

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

The paper identifies gene expression differences between human and non-human primate brains at single-cell resolution, revealing rapid evolution in specific cell types.

Molecular Mechanisms Driving Bistable Switch Behavior in Xylem Cell Differentiation

The paper models the molecular mechanisms of bistable switching in xylem cell differentiation using whole root and single-cell data, identifying VND7's role and a novel regulatory cycle.

A negative feedback mechanism in the insulin-regulated glucose homeostasis in Japanese flounder Paralichthys olivaceus by two ways of glucose administration

This study compares glucose administration methods in Japanese flounder, showing different insulin and brain-gut peptide responses, and suggests a negative feedback mechanism in glucose homeostasis.

Visualization And Label-Free Quantification Of Microfluidic Mixing Using Quantitative Phase Imaging

The paper visualizes and quantifies microfluidic mixing using quantitative phase imaging without exogenous labels, validated against Fick's law calculations.