Z. He

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

Promoted Read-through and Mutation Against Pseudouridine-CMC by an Evolved Reverse Transcriptase

The paper develops a method called Mut-Psi-seq to map pseudouridine at base-resolution using an evolved reverse transcriptase and chemical labeling, revealing new Psi sites in human rRNAs.

Spatial resolution of transcriptomic plasticity states underpinning lethal morphologies in lung adenocarcinoma

This study uses spatial transcriptomics to analyze gene expression in lung adenocarcinoma morphologies, revealing plasticity and gene expression trajectories linked to lethal growth patterns.

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

Epigenetic regulation of alveolar macrophage homeostasis by histone deacetylase 1 and 2

This study shows HDAC1 and HDAC2 are essential for alveolar macrophage homeostasis by suppressing Bim expression and co-regulating differentiation with LSD1.

PAN2-PAN3 deadenylase activity is selectively required for mitotic robustness under microtubule stress

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs

This study uses the AsGM1 membrane lipid signature to distinguish NK cells and ILC1s, capturing their plasticity across tissues and conditions.

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

Comparative transcriptomic and lipidomic analysis of fatty acid accumulation in three Camellia oleifera varieties during maturation

This study compares transcriptomic and lipidomic profiles of three Camellia oleifera varieties during seed maturation, linking fatty acid composition to gene expression patterns.

Heterozygosity for Crohn's Disease Risk Allele of ATG16L1 Protects against Bacterial Infection

The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Brain transcriptomics reveals features of the host response after dengue virus type I infection induced central nervous system injury in AGB6 mice

This study uses brain transcriptomics to identify host response features in AGB6 mice infected with dengue virus type I, revealing cytokine-cytokine receptor interaction as a key pathway in neurological damage.

The P2 protein of wheat yellow mosaic virus acts as a VSR to facilitate virus infection in wheat plants

WYMV P2 protein acts as a VSR by interfering with CaM-CAMTA3 interaction to enhance virus systemic infection in wheat.

An integrated transcriptomic cell atlas of human endoderm-derived organoids

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer

This study shows that inhibiting β-catenin/CBP interaction with ICG-001 alters 3D chromatin structure in pancreatic cancer, affecting insulin signaling and promoting tumor growth.

One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

This paper shows that engineered T cells can cure asthma in mice by targeting eosinophils and blocking inflammatory cytokines.

Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis

The paper uses single-cell RNA sequencing to identify molecular pathways and immune subsets in immune-related myocarditis and myositis, finding clonally expanded CD8+ T cells and specific myeloid cell populations associated with adverse outcomes.

Urban non-point source pollutants cause microbial community homogenization via increasing deterministic processes

This study shows urban non-point source pollutants homogenize microbial communities by increasing deterministic processes and reducing habitat heterogeneity.

Structure and function of the human mitochondrial MRS2 channel

This study investigates the structure and function of the human MRS2 channel, revealing its Ca2+-regulated, non-selective ion permeability and a conserved arginine ring that prevents proton motive force collapse.

A gel-coated air-liquid-interface culture system with tunable substrate stiffness matching healthy and diseased lung tissues

This paper introduces a gel-coated air-liquid-interface culture system that mimics the stiffness of healthy and fibrotic lung tissues, showing enhanced cell migration on pathological stiffness.

Contribution of the delta-class glutathione S-transferase to agrochemical adaptation in Apis mellifera

This study characterizes AmGSTD1, a delta-class GST in honey bees, showing its role in agrochemical detoxification and antioxidative stress through structural and functional analysis.

A trade-off between proliferation and defense in the fungal pathogen Cryptococcus at alkaline pH is controlled by the transcription factor GAT201

This paper identifies Gat201 as a transcription factor controlling a trade-off between capsule production and proliferation in Cryptococcus neoformans at alkaline pH.

Seasonal Variation in Bacterial Community Structures of Mangrove Sediments

This study examines seasonal variations in mangrove sediment bacterial communities and identifies factors influencing their assembly mechanisms.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Transcriptomic Analysis Of The Ocular Posterior Segment Completes A Cell Atlas Of The Human Eye

This paper completes a cell atlas of the human eye by analyzing the posterior segment using snRNA-seq, identifying 37 cell types and mapping glaucoma-associated gene expression.

Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum

This study identifies novel epigenomic features in sorghum, including H3K27me3 islands and the role of histone marks in regulating tissue-specific and stress-responsive genes.

Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.