BiophysicsbioRxiv
Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions
S. Bobone, L. Pannone, B. Biondi…·L. Stella
This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.
DOI 10.1021/acs.jmedchem.1c01371