Engineering protein-specific proteases: targeting active RAS
Y. Chen, E. A. Toth, B. Ruan, E. J. Choi, R. Simmerman, Y. Chen, Y. He, R. Wang, R. Godoy-Ruiz, H. King, G. Custer, D. T. Gallagher, D. A. Rozak, M. Soloman, S. Muro, , P. N. Bryan
This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.
bioRxiv · Sep 21, 2020Biochemistry