Author

D. J. Weber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Biophysics· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Assay:electrophysiology· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. K. Trevathan· 4 shared K. A. Ludwig· 4 shared M. Franke· 4 shared A. J. Shoffstall· 3 shared L. E. Fisher· 3 shared A. des Georges· 2 shared A. N. Dalrymple· 2 shared E. Pozharski· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBioengineering

J. K. Trevathan

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Author profile →

10 papers

Recent·Most cited

Computational modeling of dorsal root ganglion stimulation using an Injectrode

S. Bhowmick, R. D. Graham, N. Verma, J. K. Trevathan, M. Franke, S. Nieuwoudt, L. E. Fisher, A. J. Shoffstall, D. J. Weber, K. A. Ludwig, S. Lempka

The paper models the Injectrode system to determine how design parameters affect neural activation, finding that larger surface area reduces pain-related activation.

bioRxiv · Sep 20, 2023Bioengineering

Membrane binding and pore formation is Ca2+-dependent for the Clostridioides difficile binary toxin

D. L. Abeyawardhane, S. E. Sevdalis, K. A. Adipietro, R. Godoy-Ruiz, K. M. Varney, I. F. Nawaz, A. X. Spittel, R. R. Rustandi, V. I. Silin, A. des Georges, E. Pozharski, D. J. Weber

This study shows that Ca2+ dissociation from CDTb's RBD1 triggers pore formation in endosomal membranes, differing from other binary toxins that rely on pH changes.

bioRxiv · Aug 18, 2023 · PreprintBiophysics

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

I. Lee, A. Surendran, S. Fleury, I. Gimino, A. Curtiss, C. Fell, D. Shiwarski, O. El-Refy, B. Rothrock, S. Jo, T. Schwartzkopff, A. Singh Mehta, S. John, X. Ji, G. Nikiforidis, , T. Cohen-Karni

This paper introduces an electrocatalytic system for on-site oxygen production to support cell therapies under hypoxic conditions.

bioRxiv · Jun 5, 2023Bioengineering

CD36 homologs determine microbial resistance to the Lyme disease spirochete

A. J. O'Neal, N. Singh, I. S. Forrest, A. Rolandelli, X. Wang, D. K. Shaw, B. D. Young, S. Narasimhan, S. Dutta, G. A. Snyder, L. Marnin, L. R. Butler, S. Samaddar, M. T. Mendes, F. E. C. Paz, , J. H. F. Pedra

The paper identifies CD36 homologs as conserved lipid receptors mediating anti-Borrelia immunity in both ticks and humans.

bioRxiv · Feb 9, 2022 · PreprintImmunology

Augmented Transcutaneous Stimulation Using an Injectable Electrode

N. Verma, R. D. Graham, J. Mudge, J. K. Trevathan, M. Franke, A. J. Shoffstall, J. Williams, A. N. Dalrymple, L. E. Fisher, D. J. Weber, S. F. Lempka, K. A. Ludwig

This paper presents an electroquasistatic model to improve transcutaneous power delivery to an injectable electrode by accounting for capacitive and resistive mechanisms.

bioRxiv · Sep 29, 2021Bioengineering

Stimulation of the Dorsal Root Ganglion using an Injectrode

A. N. Dalrymple, J. E. Ting, R. Bose, J. K. Trevathan, S. Nieuwoudt, S. F. Lempka, M. Franke, K. A. Ludwig, A. Shoffstall, L. E. Fisher, D. J. Weber

This study compares the effectiveness of an injectable polymer electrode (Injectrode) and a traditional metal electrode in stimulating dorsal root ganglion afferent fibers, finding similar activation thresholds and recruitment rates.

bioRxiv · Aug 16, 2021Bioengineering

Dynamic Detection and Reversal of Myocardial Ischemia Using an Artificially Intelligent Bioelectronic Medicine

P. D. Ganzer, M. S. Loeian, S. R. Roof, B. Teng, L. Lin, D. A. Friedenberg, I. W. Baumgart, E. C. Meyers, K. S. Chun, A. Rich, W. W. Muir, D. J. Weber, R. L. Hamlin

This study uses artificial neural networks to detect and reverse myocardial ischemia through bioelectronic medicine, achieving high accuracy and effective biomarker reversal.

bioRxiv · Dec 30, 2020 · PreprintBioengineering

Engineering protein-specific proteases: targeting active RAS

Y. Chen, E. A. Toth, B. Ruan, E. J. Choi, R. Simmerman, Y. Chen, Y. He, R. Wang, R. Godoy-Ruiz, H. King, G. Custer, D. T. Gallagher, D. A. Rozak, M. Soloman, S. Muro, , P. N. Bryan

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

bioRxiv · Sep 21, 2020Biochemistry

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

X. Xu, R. Ruiz, K. A. Adipietro, C. Peralta, D. Ben-Hail, K. M. Varney, M. E. Cook, B. M. Roth, P. T. Wilder, T. Cleveland, A. Grishaev, H. Neu, S. Michel, W. Yu, D. Beckett, , D. J. Weber

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.

bioRxiv · Nov 10, 2019 · PreprintBiophysics

A Truly Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite

J. K. Trevathan, I. Baumgart, E. N. Nicolai, B. A. Gosink, A. J. Asp, M. L. Settell, S. R. Polaconda, K. Malerick, S. K. Brodnick, W. Zeng, B. E. Knudsen, A. L. McConico, Z. Sanger, J. H. Lee, J. M. Aho, , A. J. Shoffstall

The paper introduces an injectable neural stimulation electrode made from a polymer/metal composite that conforms to neural structures and performs similarly to traditional electrodes in rats and swine.

bioRxiv · Jul 18, 2019Bioengineering