Author

J. Orban

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Y. Chen· 4 shared Y. He· 4 shared B. Ruan· 2 shared D. T. Gallagher· 2 shared E. J. Choi· 2 shared M. K. Jolly· 2 shared P. Kulkarni· 2 shared P. N. BRYAN· 2 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiophysics

Y. Chen

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Author profile →

4 papers

Recent·Most cited

Rules for designing protein fold switches and their implications for the folding code

Y. Chen, Y. He, B. Ruan, E. J. Choi, Y. Chen, D. Motabar, T. Solomon, R. Simmerman, T. Kauffman, D. T. Gallagher, J. Orban, P. N. BRYAN

The paper designs protein fold switches between three common small folds and identifies rules for engineering dimorphic sequences that can populate multiple folds.

bioRxiv · May 18, 2021 · PreprintBiophysics

Engineering protein-specific proteases: targeting active RAS

Y. Chen, E. A. Toth, B. Ruan, E. J. Choi, R. Simmerman, Y. Chen, Y. He, R. Wang, R. Godoy-Ruiz, H. King, G. Custer, D. T. Gallagher, D. A. Rozak, M. Soloman, S. Muro, , P. N. Bryan

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

bioRxiv · Sep 21, 2020Biochemistry

A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis

A. Mohanty, A. Nam, A. Pozhitkov, S. Bhattacharya, L. Yang, A. Nathan, X. Wu, S. Srivastava, I. Mambetsariev, M. Nelson, R. Pangeni, D. Raz, Y. Chen, Y. He, J. Orban, , R. Salgia

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

bioRxiv · Sep 25, 2019Cancer Biology

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer

X. Lin, S. Roy, M. K. Jolly, F. Bocci, N. Schafer, M.-Y. Tsai, Y. Chen, Y. He, A. Grishaev, K. Weninger, J. Orban, P. Kulkarni, G. Rangarajan, H. Levine, J. N. Onuchic

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

bioRxiv · Feb 22, 2018Biophysics