Author

G. D. Jay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

K. A. Thomsson· 3 shared N. G. Karlsson· 3 shared O. Rolfson· 3 shared R. Krawetz· 3 shared S. Huang· 3 shared T. A. Schimdt· 3 shared T. Eisler· 3 shared A. Struglics· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPathology

K. A. Thomsson

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Author profile →

4 papers

Recent·Most cited

The level of synovial human VEGFA, IL-8 and MIP-1α correlate with truncation of lubricin glycans in osteoarthritis

S. Huang, K. A. Thomsson, C. Jin, H. Ryberg, N. Das, A. Struglics, O. Rolfson, L. I. Björkman, T. Eisler, T. A. Schimdt, G. D. Jay, R. Krawetz, N. G. Karlsson

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

bioRxiv · Mar 11, 2021 · PreprintPathology

Proteoglycan 4 (PRG4) expression and functionin dry eye associated inflammation

N. G. Menon, R. Goyal, C. Lema, P. Woods, G. D. Jay, L. H. Shapiro, R. L. Redfern, M. Ghosh, T. A. Schimdt

This study examines PRG4 expression and function in dry eye disease, showing its anti-inflammatory effects and role in ocular surface homeostasis.

bioRxiv · Oct 1, 2020Biochemistry

Core-2 O-glycans are required for Galectin-3 interaction with the osteoarthritis related protein lubricin

S. A. Flowers, K. A. Thomsson, L. Ali, S. Huang, Y. Mthembu, S. C. Regmi, J. Holgersson, T. A. Schimdt, O. Rolfson, L. I. Bjorkman, M. Sundqvist, A. Karlsson, G. D. Jay, T. Eisler, R. Krawetz, N. G. Karlsson

The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.

bioRxiv · Dec 20, 2019Biochemistry

Cathepsin G Degrades Synovial Fluid Lubricin: Relevance For Osteoarthritis Pathogenesis

S. Huang, K. A. Thomsson, C. Jin, S. Alweddi, A. Struglics, O. Rolfson, L. I. Bjorkman, S. Kalamajsk, T. A. Schmidt, G. D. Jay, R. Krawetz, N. G. Karlsson, T. Eisler

This study shows that cathepsin G degrades lubricin in synovial fluid, contributing to osteoarthritis pathogenesis by reducing joint lubrication.

bioRxiv · Oct 15, 2019 · PreprintPathology