Author

R. Krawetz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

G. D. Jay· 3 shared K. A. Thomsson· 3 shared N. G. Karlsson· 3 shared O. Rolfson· 3 shared S. Huang· 3 shared T. Eisler· 3 shared A. Struglics· 2 shared C. Jin· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPathology

G. D. Jay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

H. Peters, P. Potla, J. S. Rockel, T. Tockovska, C. Pastrello, I. Jurisica, K. D. Santos, S. Vohra, S. Lively, K. Perry, N. Looby, S. H. Li, V. Chandran, K. Hueniken, P. Kaur, , M. Kapoor

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.

bioRxiv · Apr 4, 2024Cell Biology

Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling

J. Nguyen, L. Wang, W. Lei, Y. Hu, N. Gulati, C. Chavez-Madero, H. Ahn, H. J. Ginsberg, R. Krawetz, M. Brandt, T. Betz, P. M. Gilbert

This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.

bioRxiv · Aug 8, 2023Bioengineering

The level of synovial human VEGFA, IL-8 and MIP-1α correlate with truncation of lubricin glycans in osteoarthritis

S. Huang, K. A. Thomsson, C. Jin, H. Ryberg, N. Das, A. Struglics, O. Rolfson, L. I. Björkman, T. Eisler, T. A. Schimdt, G. D. Jay, R. Krawetz, N. G. Karlsson

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

bioRxiv · Mar 11, 2021 · PreprintPathology

Core-2 O-glycans are required for Galectin-3 interaction with the osteoarthritis related protein lubricin

S. A. Flowers, K. A. Thomsson, L. Ali, S. Huang, Y. Mthembu, S. C. Regmi, J. Holgersson, T. A. Schimdt, O. Rolfson, L. I. Bjorkman, M. Sundqvist, A. Karlsson, G. D. Jay, T. Eisler, R. Krawetz, N. G. Karlsson

The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.

bioRxiv · Dec 20, 2019Biochemistry

Cathepsin G Degrades Synovial Fluid Lubricin: Relevance For Osteoarthritis Pathogenesis

S. Huang, K. A. Thomsson, C. Jin, S. Alweddi, A. Struglics, O. Rolfson, L. I. Bjorkman, S. Kalamajsk, T. A. Schmidt, G. D. Jay, R. Krawetz, N. G. Karlsson, T. Eisler

This study shows that cathepsin G degrades lubricin in synovial fluid, contributing to osteoarthritis pathogenesis by reducing joint lubrication.

bioRxiv · Oct 15, 2019 · PreprintPathology