C. Jin

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

Ribosome biogenesis factor AtRRB1 confers pollen heat stress tolerance in Arabidopsis

This study identifies AtRRB1 as a ribosome biogenesis factor that enhances heat stress tolerance in Arabidopsis pollen by supporting protein synthesis and ER function during microspore development.

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.

Visualizing the M2 muscarinic acetylcholine receptor activation regulated by aromatic ring dynamics

This study uses atomic-level simulations to show how ligand binding modulates conformational dynamics of the M2 muscarinic receptor, revealing key aromatic residue interactions involved in activation.

Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron

This study identifies Ruminococcus torques as a keystone mucin-degrading bacterium that releases oligosaccharides accessible to Bacteroides thetaiotaomicron, linking its role to inflammatory bowel disease.

Structural basis of anticancer drug recognition and amino acid transport by LAT1

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges.

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models

The paper presents a single-cell RNA-sequencing dataset of human and mouse adipogenesis models, revealing three cell clusters during differentiation.

Distinct activation mechanisms of β-arrestin 1 revealed by 19F NMR spectroscopy

This study uses 19F NMR to show that different GPCR phosphopeptides and PIP2 induce distinct activation mechanisms in β-arrestin 1.

Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

The paper identifies new milk oligosaccharide structures across nine species, revealing widespread LacdiNAc motifs and glucuronic acid-containing MOs with immunomodulatory effects.

AKIR-1 Regulates Proteasome Localization and Function in Caenorhabditis elegans

This study identifies AKIR-1 as a regulator of proteasome localization and function in C. elegans, showing its role in nuclear proteasome transport and proteostasis.

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

This study identifies sialidases and fucosidases in Akkermansia muciniphila that degrade mucin glycans and enable nutrient sharing with gut bacteria.

Heat stress induces unreduced male gamete formation by targeting meiocyte translation

The paper identifies TAM's role in maintaining meiotic translation under heat stress, preventing premature meiotic exit and promoting unreduced gamete formation in Arabidopsis.

The thermodynamic state of aerobic glycolytic flux plays a critical role in stabilizing aerobic glycolytic flux of cancer cells

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

Reproducing extracellular matrix adverse remodelling of non-ST myocardialinfarction in a large animal model

This paper develops an ovine model of NSTEMI and identifies ECM and glycan alterations in post-ischaemic tissue.

High axial-resolution optical stimulation of neurons in vivo via two-photon optogenetics with speckle-free beaded-ring pattern

This paper introduces a beaded-ring pattern for two-photon optogenetics to improve axial resolution in vivo, showing a 24% improvement over disk patterns when stimulating multiple neurons.

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

Novel pectin from crude polysaccharide of Syzygium aromaticum against SARS-CoV-2 activities by targeting 3CLpro

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

Integrated Multi-Omics Data Reveals the Molecular Subtypes of Prostate Cancer

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

The level of synovial human VEGFA, IL-8 and MIP-1α correlate with truncation of lubricin glycans in osteoarthritis

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

SUMOylation of GMFB regulates the stability and function of GMF in RPE cells under oxidative stress and inflammation

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor

This study uses NMR to show that the PAM LY2119620 changes the structure and dynamics of M2R in both extracellular and G-protein coupling domains, stabilizing distinct conformations not seen with orthosteric agonists.

Single molecule tracking of AMPA receptors shows the role of synaptic insertion during maintenance of chemical LTP

The paper uses single-molecule tracking to show that synaptic insertion, not lateral diffusion, contributes to maintaining chemical LTP by increasing AMPA receptor subunits at synapses.

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

A robust and versatile nanobody platform for drug delivery

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

K+ uptake and root-to-shoot allocation in Arabidopsis require coordination of nitrate transporter1/peptide transporter family member NPF6.3/NRT1.1

This study shows that NRT1.1 in Arabidopsis roots coordinates with K+ channels to regulate uptake and allocation of potassium.

Butyrate producing Clostridiales utilize distinct human milk oligosaccharides correlating to early colonization and prevalence in the human gut

The paper identifies HMO utilization pathways in Roseburia and Eubacterium that enable co-growth with Akkermansia muciniphilia and highlight distinct HMO utilization phylotypes in the early gut microbiota.

Introduction of the Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei leads to abnormal polarity and improves the ligno-cellulose degradation

This study introduces Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei, altering N-glycan processing and improving lignocellulose degradation while causing abnormal polarity and secretion phenotypes.