Cancer BiologybioRxivPreprint
Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability
R. Barbosa, A. Q. Xu, D. D'Andrea…·D. P. Calado
This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.
DOI 10.1101/2020.04.12.038414