Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis
G. Grillo, B. Nadorp, A. Qamra, A. Mitchell, C. Arlidge, A. Nand, N. Takayama, A. Murison, S. A. M. Tonekaboni, A. Arruda, J. Wang, M. Minden, O. Deniz, H. Boutzen, J. Dick, M. Lupien
The paper identifies transposable elements (TEs) as genetic drivers of stemness in normal and leukemic hematopoiesis, showing their role in maintaining stem cell properties through chromatin accessibility.
bioRxiv · Feb 16, 2021Cancer Biology