Author

C. Arlidge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

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Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Assay:ChIP-seq· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

M. Lupien· 6 shared A. Murison· 3 shared H. Boutzen· 3 shared A. Arruda· 2 shared A. Mitchell· 2 shared B. Nadorp· 2 shared G. Grillo· 2 shared J. Dick· 2 shared

Activity by Year

2020-2024 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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6 shared papersCancer Biology

M. Lupien

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6 papers

Recent·Most cited

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties

H. Boutzen, A. Murison, J. C. Y. Wang, C. Arlidge, M. Lupien, K. B. Kaufmann, J. E. Dick

The paper identifies two distinct leukemia stem cell subtypes with unique transcriptional, epigenetic, and functional properties using a patient-derived cell model and single-cell analysis.

bioRxiv · Feb 9, 2024Cancer Biology

A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment

H. Boutzen, M. Chan-Seng-Yue, A. Murison, N. Mbong, E. Wagenblast, C. Arlidge, S. A. Madani Tonekaboni, E. Orouji, A. Arruda, A. Mitchell, F. Notta, M. Lupien, M. Minden, K. Kaufmann, J. Dick

bioRxiv · Mar 1, 2022 · PreprintCancer Biology

Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis

G. Grillo, B. Nadorp, A. Qamra, A. Mitchell, C. Arlidge, A. Nand, N. Takayama, A. Murison, S. A. M. Tonekaboni, A. Arruda, J. Wang, M. Minden, O. Deniz, H. Boutzen, J. Dick, M. Lupien

The paper identifies transposable elements (TEs) as genetic drivers of stemness in normal and leukemic hematopoiesis, showing their role in maintaining stem cell properties through chromatin accessibility.

bioRxiv · Feb 16, 2021Cancer Biology

Cis-Regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Primary Prostate Cancer

J. R. Hawley, S. Zhou, C. Arlidge, G. Grillo, K. Kron, R. Hugh-White, T. van der Kwast, M. Fraser, P. C. Boutros, R. G. Bristow, M. Lupien

The paper shows that structural variants causing cis-regulatory element hijacking have a greater impact on gene expression than changes in three-dimensional chromatin topology in primary prostate cancer.

bioRxiv · Jan 5, 2021Cancer Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology

Human papillomavirus integration transforms chromatin to drive oncogenesis

M. Karimzadeh, C. Arlidge, A. Rostami, M. Lupien, S. V. Bratman, M. M. Hoffman

This study shows HPV integration introduces CTCF binding sites, altering chromatin and upregulating essential genes in HPV+ cancers.

bioRxiv · Feb 12, 2020Cancer Biology