G. Gunasingh

Formation and growth of co-culture tumour spheroids: new compartment-based mathematical models and experiments

This paper develops new compartment-based mathematical models and analyzes experimental data to better understand co-culture tumour spheroid formation and growth.

Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

This study investigates how time-dependent oxygen availability affects tumour spheroid growth and identifies new adaptation mechanisms.

A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling

This paper develops a stochastic individual-based model of 4D tumour spheroids and validates it against experimental data from human melanoma cell line experiments.

Designing and interpreting 4D tumour spheroid experiments

This study evaluates 4D tumour spheroid experiments by comparing designs and identifying reliable insights using mathematical modeling and statistical analysis.

Quantitative analysis of tumour spheroid structure

This study quantifies tumour spheroid structure, showing that limiting structure is independent of initial seeding density and spheroid size.

Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture

This paper shows that melanoma phenotypic heterogeneity is controlled by cell-ECM crosstalk, altering tumor microarchitecture and mechanotransduction.

Synchronised oscillations in growing cell populations are explained by demographic noise

This study shows that synchronized oscillations in growing cell populations arise from demographic noise rather than active cell-cell communication.

Examining go-or-grow using fluorescent cell-cycle indicators and cell cycle-inhibiting drugs

This study examines the go-or-grow hypothesis in melanoma cells using fluorescent cell-cycle indicators and drugs, finding no support for the hypothesis as motility is independent of cell-cycle phase.

Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronisation in cell proliferation

The paper shows that cell proliferation assays exhibit hidden synchronisation, which is modeled using a multi-stage mathematical model to explain apparent exponential growth.

Stochastic models of cell invasion with fluorescent cell cycle indicators

The paper develops a stochastic model of cell invasion in scratch assays using fluorescent cell cycle indicators and validates it with experimental data.

Mathematical models for cell migration with real-time cell cycle dynamics

This paper develops mathematical models to describe cell migration and cell cycle dynamics using FUCCI data, showing they can predict spatial and temporal patterns of cell density.