Author

M. E. Fane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

G. M. Alicea· 3 shared A. Kossenkov· 2 shared A. T. Weeraratna· 2 shared M. Herlyn· 2 shared M. Xiao· 2 shared V. W. Rebecca· 2 shared A. Carey· 1 shared A. G. Smith· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

G. M. Alicea

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

G. M. Alicea, M. E. Portuallo, P. Patel, M. E. Fane, A. Carey, D. W. Speicher, A. Kossenkov, V. W. Rebecca, D. Wirtz, A. T. Weeraratna

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

bioRxiv · May 2, 2023Cancer Biology

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

V. W. Rebecca, M. Xiao, A. Kossenkov, T. Godok, G. S. Brown, D. Fingerman, G. M. Alicea, M. Wei, H. Ji, J. Bravo, Y. Chen, M. E. Fane, J. Villanueva, K. L. Nathanson, Q. Liu, , M. Herlyn

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

bioRxiv · Jan 20, 2023 · PreprintCancer Biology

clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ

I. Dardani, B. L. Emert, Y. Goyal, C. L. Jiang, A. Kaur, J. Lee, S. H. Rouhanifard, G. M. Alicea, M. E. Fane, M. Xiao, M. Herlyn, A. T. Weeraratna, A. Raj

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

bioRxiv · Mar 16, 2022Bioengineering

Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture

L. Spoerri, C. A. Tonnessen-Murray, G. Gunasingh, D. S. Hill, K. A. Beaumont, R. J. Jurek, J. Chauhan, G. C. Vanwalleghem, M. E. Fane, S. M. Daignault-Mill, N. Matigian, G. M. Boyle, E. K. Scott, A. G. Smith, S. J. Stehbens, , N. K. Haass

This paper shows that melanoma phenotypic heterogeneity is controlled by cell-ECM crosstalk, altering tumor microarchitecture and mechanotransduction.

bioRxiv · Jun 9, 2020 · PreprintCancer Biology