M. Simpson

Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model

This study shows that CDTb, a component of C. difficile binary toxin, contributes to virulence by inducing inflammation and restoring virulence in a hamster model when expressed alone.

Clostridium difficile binary toxin (CDT) is recognized by the TLR2/6 heterodimer to induce an NF-κB response

The paper shows that CDT is recognized by the TLR2/6 heterodimer, leading to NF-κB and MAPK pathway activation in mice during CDI.

Spatial structure arising from chase-escape interactions with crowding

This paper studies how directional interactions between two species lead to spatial patterns, using an individual-based model and its deterministic approximation.

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis

The paper shows that introducing Clostridium scindens into the gut microbiota epigenetically alters bone marrow and provides protection against Entamoeba histolytica infection.

Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronisation in cell proliferation

The paper shows that cell proliferation assays exhibit hidden synchronisation, which is modeled using a multi-stage mathematical model to explain apparent exponential growth.

Using experimental data and information criteria to guide model selection for reaction--diffusion problems in mathematical biology

This study uses Bayesian analysis and information criteria to select a reaction-diffusion model for cell invasion, showing that model complexity and residual errors should both be considered.

Self-organization controls expression more than abundance of molecular components of transcription and translation in confined cell-free gene expression

This study shows that self-organization, not molecular abundance, drives expression efficiency and noise in cell-free gene expression systems.

Mechanistic and experimental models of cell migration reveal the importance of intercellular interactions in cell invasion

This paper uses experimental and modeling approaches to show that intercellular interactions, particularly pushing, significantly influence cell invasion.

A Bayesian sequential learning framework to parameterise continuum models of melanoma invasion into human skin

The paper introduces a Bayesian sequential learning framework to estimate parameters of a melanoma invasion model using increasingly complex experimental data.

Extended logistic growth model for heterogeneous populations

This paper extends the logistic growth model to account for heterogeneity in cell proliferation rates, showing that ignoring this variability can lead to misleading results in proliferation assays.

Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue

Mathematical models for cell migration with real-time cell cycle dynamics

This paper develops mathematical models to describe cell migration and cell cycle dynamics using FUCCI data, showing they can predict spatial and temporal patterns of cell density.

Discrete and continuum approximations for collective cell migration in a scratch assay with cell size dynamics

This paper develops a stochastic model and continuum approximations to study collective cell migration in scratch assays with cell size dynamics, showing improved accuracy with moment dynamics over mean-field approximations.

A Feedback Motif that Breaks the Fundamental Limit on Noise Suppression to Stabilize Fate

The paper identifies a feedback motif in HIV that suppresses noise more effectively than traditional methods, stabilizing cellular commitment to the active-replication state.

Co-operation, competition and crowding: a discrete framework linking Allee kinetics, nonlinear diffusion, shocks and sharp-fronted travelling waves

The paper develops a discrete model of invasion processes with different birth, death, and movement rates for individuals in or out of the bulk population, showing shock-fronted travelling waves under strong Allee effect and nonlinear diffusion.