Author

J. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 3 Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Approach:statistical model· 3 Organism:bacteria (other)· 2

Frequent Co-Authors

A. Letai· 3 shared E. C. Garner· 2 shared A. Conway· 1 shared A. G. Henssen· 1 shared A. Kentsis· 1 shared A. Naranjo· 1 shared A. Parivesh· 1 shared A. R. Agra de Almeida Quadros· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Letai

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

J. Lopez-Erauskin, M. Bravo-Hernandez, M. Presa, M. W. Baughn, Z. Melamed, M. S. Beccari, A. R. Agra de Almeida Quadros, A. Zuberi, K. Ling, O. Platoshyn, E. Nino-Jara, I. S. Ndayambaje, O. Arnold-Garcia, M. McAlonis-Downes, L. Cabrera, , C. Lagier-Tourenne

This study shows that loss of stathmin-2 causes neurofilament-dependent axonal collapse, leading to motor and sensory deficits and denervation in mice.

bioRxiv · Dec 11, 2022Cell Biology

Mitotic chromosomes scale to nucleo-cytoplasmic ratio and cell size in Xenopus

C. Y. Zhou, B. Dekker, Z. Liu, H. Cabrera, J. Ryan, J. Dekker, R. Heald

This study shows mitotic chromosomes scale with cell size and nucleo-cytoplasmic ratio in Xenopus, distinct from other subcellular structures, through mechanisms involving condensin I and importin pathways.

bioRxiv · Oct 20, 2022Cell Biology

Reprograming human fibroblasts into Sertoli cells: a tool for personalized medicine

A. Parivesh, E. Delot, A. Reyes, J. Ryan, S. Bhattacharya, V. Harley, E. Vilain

This paper reprograms human fibroblasts into Sertoli cells to improve diagnosis of Disorders of Sex Development by creating a model that mimics embryonic gonadal development.

bioRxiv · Aug 25, 2022 · PreprintCell Biology

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML

S. Lin, C. Larrue, B. K. A. Seong, N. V. Dharia, M. Kuljanin, C. Wechsler, G. Kugener, A. Robichaud, A. Conway, T. N. Mashaka, S. Mouche, B. Adane, J. Ryan, J. D. Mancias, S. T. Younger, , K. Stegmaier

This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.

bioRxiv · Dec 28, 2020Cancer Biology

Dynamics of bacterial cell division: Z ring condensation is essential for cytokinesis

G. R. Squyres, M. J. Holmes, S. R. Barger, B. R. Pennycook, J. Ryan, V. T. Yan, E. C. Garner

The paper investigates the role of FtsZ binding proteins in bacterial cytokinesis, finding that Z ring condensation is essential for cell division.

bioRxiv · Jun 30, 2020Microbiology

Metaproteomic responses of in vitro gut microbiomes to resistant starches: the role of resistant starch type and inter-individual variations

L. Li, J. Ryan, Z. Ning, X. Zhang, J. Mayne, M. Lavallee-Adam, A. Stintzi, D. Figeys

This study examines how different types of resistant starches affect gut microbiome protein expression and functional pathways, revealing inter-individual variations in responses.

bioRxiv · Feb 28, 2020Microbiology

Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor

M. V. Ortiz, S. Ahmed, M. Burns, A. G. Henssen, T. Hollmann, I. MacArthur, S. Gunasekerea, L. Gaewsky, G. Bradwin, J. Ryan, A. Letai, Y. He, A. Naranjo, Y.-Y. Chi, M. LaQuaglia, , A. Kentsis

This study identifies prohibitin as a urine biomarker for Wilms tumor relapse and shows it promotes chemotherapy resistance by disrupting mitochondrial apoptosis.

bioRxiv · Dec 30, 2018Cancer Biology

Cell Diameter in Bacillus subtilis is Determined by the Opposing Actions of Two Distinct Cell Wall Synthetic Systems

M. Dion, M. Kapoor, Y. Sun, S. Wilson, J. Ryan, A. Vigouroux, S. van Teeffelen, R. Oldenbourg, E. C. Garner

The paper investigates how two cell wall synthesis systems in Bacillus subtilis determine cell diameter through their opposing effects on growth and width.

bioRxiv · Aug 22, 2018Microbiology

Stochastic models of cell invasion with fluorescent cell cycle indicators

M. J. Simpson, W. Jin, S. T. Vittadello, T. Tambyah, J. Ryan, G. Gunasingh, N. Haass, S. McCue

The paper develops a stochastic model of cell invasion in scratch assays using fluorescent cell cycle indicators and validates it with experimental data.

bioRxiv · May 24, 2018Biophysics

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

C. B. Mulholland, F. R. Traube, E. Parsa, E.-M. Eckl, M. Schoenung, M. Modic, M. D. Bartoschek, P. Stolz, J. Ryan, T. Carell, H. Leonhardt, S. Bultmann

The paper compares TET1 and TET2 contributions to cytosine oxidation during naive to primed pluripotency transition, finding distinct and differentiation-dependent roles in 5hmC and 5fC formation.

bioRxiv · Mar 13, 2018Cell Biology