G. Hammond

A Polybasic Domain in aPKC Mediates Par-6-Dependent Control of Plasma Membrane Targeting and Kinase Activity

This study identifies a polybasic domain in aPKC that mediates PM targeting and kinase activity through Par-6 interaction and allosteric regulation.

SAC1 Degrades its Lipid Substrate PtdIns4P in the Endoplasmic Reticulum to Maintain a Steep Chemical Gradient with Donor Membranes

This paper shows SAC1 degrades PtdIns4P in the ER to maintain a gradient, revealing its obligate cis activity in lipid traffic.