A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane
R. C. Wills, C. P. Doyle, J. P. Zewe…·G. R. Hammond
The paper identifies PIP4K as a sensor and negative regulator of PI(4,5)P2 synthesis, revealing a homeostatic mechanism that tunes membrane functions.