Cell BiologybioRxiv
Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue
M. Moruzzi, A. Nestor-Bergmann, G. K. Goddard…·S. Woolner
This study shows that kRasV12 oncogene-expressing clusters induce anisotropic strain in host tissue, increasing cell division and altering division orientation, which can be reversed by reducing actomyosin contractility.
DOI 10.1016/j.cub.2021.05.023