PhysiologybioRxivPreprint
Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging
M. A. Petr, L. M. Carmona-Marin, T. Tulika…·M. Scheibye-Knudsen
This study shows that ketones like beta-hydroxybutyrate reduce premature aging features in Cockayne syndrome models by enhancing transcriptional readthrough of DNA secondary structures through histone acetylation.
DOI 10.1101/2022.03.08.483430