G. Khuu

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy

This study identifies a RAB7A phosphoswitch regulated by TBK1 that modulates Rubicon and Pacer interactions to control PINK1/Parkin-dependent mitophagy.

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

Temporal landscape of mitochondrial proteostasis governed by the UPRmt

This study develops MitoPQ, a functional proteomics framework, to analyze how the UPRmt maintains mitochondrial proteostasis during stress and identifies oxidative phosphorylation as a key target.

Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.