E. Adriaenssens

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

This study designs and characterizes K1K1, a minimal MET receptor agonist made from two kringle 1 domains of HGF/SF, showing stability and biological activity comparable to native HGF/SF in vitro and in a mouse liver disease model.

This study shows that BAG3 Pro209 mutants cause aggresome formation and disrupt chaperone-assisted selective autophagy, leading to protein homeostasis loss regardless of clinical phenotype.

This study investigates how the P182L mutation in HSP27's IxI/V motif disrupts protein interactions, leading to aggregation and disease.

The paper uses viromics to detect RNA viruses in wastewater and river systems, identifying novel norovirus genomes and suggesting zoonotic transmission risks.