W. Zheng

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

The paper examines the evolutionary arms race between 5'ppp-RNA virus and the MDA5 receptor in RIG-I-lost teleost fish, showing how MDA5 compensates for RIG-I loss and how the virus counteracts this through m6A methylation.

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

This study investigates metabolic flexibility in hair follicle stem cell-derived squamous cell carcinoma by blocking glycolysis and glutaminolysis, showing tumors can compensate by upregulating lactate consumption.

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

This study solves the structure of Myxococcus xanthus type IV pilus and shows its increased rigidity due to a large C-terminal domain in PilA, enhancing motility on varied surfaces.

This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

The paper compares placental transcriptomes and histology between native Tibetans and Han migrants, finding sex-biased expression divergence and adaptive histological changes in male-infant placentas.

The paper investigates the functional and metagenomic diversity of glycolipids produced by gut symbionts, revealing distinct biosynthetic pathways and immune-modulatory roles of different microbial species.

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

This study identifies three PRC barrel proteins in Haloferax volcanii essential for archaeal cell division, showing their conservation and role in division across haloarchaea.

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

This study shows DHA inhibits glioma migration and invasion by upregulating ecDNA-BASP1, which suppresses EMT.

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

This study identifies lysosome-poor monocyte-derived lung cells as a niche for Mtb persistence during chronic infection, suggesting a target for host-directed therapy.

The paper determines in situ structures of GspD and GspDβ secretins during translocation, revealing distinct membrane interaction patterns and translocation mechanisms.

This study investigates how transient interactions in intrinsically disordered proteins affect their conformational properties and develops a new polymer model to better interpret experimental data.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

This study investigates how specific NMDA receptor variants affect receptor function through molecular dynamics and electrophysiology, revealing that altered interactions at P552 and F652 lead to complex functional deficits.

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

This study identifies the molecular mechanism of root halotropism in Arabidopsis, showing that ABA-mediated microtubule reorientation drives anisotropic cell expansion and root twisting in response to salt stress.

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

This study examines the preclinical pharmacokinetics and in vitro ADME properties of GS-441524, showing its stability across species and varying bioavailability, supporting its development as an oral drug candidate for COVID-19.

The paper develops and validates a series of assays to identify TMPRSS2 inhibitors as potential COVID-19 treatments, identifying six compounds with varying clinical statuses.

This study investigates how allosteric regulation between actin-binding domains of plastins modulates actin bundling and cross-linking.