M. Brown

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

Teaching transposon classification as a means to crowd source the curation of repeat annotation - a tardigrade perspective

The paper presents a crowd-sourcing approach to manually curate and classify transposable elements (TEs) from tardigrade genomes, resulting in the discovery of hundreds of new TEs.

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

This paper shows MeCP2 binds methylated DNA without needing phase separation or heterochromatin, and its foci are rare in most mammals.

Analysis of evolutionary dynamics and clonal architecture in prostate cancer

This study analyzes prostate cancer clonal architecture and evolutionary dynamics in 845 tumors, finding that Black patients have more monoclonal tumors but higher recurrence rates, and identifies new mutational signatures linked to subclones.

The search behavior of terrestrial mammals

This study analyzes GPS data from 1,396 terrestrial mammals across 62 species to show how predator-prey dynamics influence movement strategies and resource search efficiency.

IRF7 impacts on prostate cancer cell survival in response to radiation

This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.

Deficiencies of Runx3 and tissue-resident CD4+ intestinal epithelial lymphocytes link intestinal dysbiosis and inflammation in mouse and human spondyloarthropathy

Deletion of CD226 in Foxp3+ T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and Function

This study shows that deleting CD226 in regulatory T cells reduces diabetes in NOD mice by enhancing Treg stability and function.

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

Vegetation formation in Staphylococcus aureus endocarditis inversely correlates with RNAIII and sarA expression in invasive clonal complex 5 (CC5) isolates

Men in menopause? Experimental verification of the mate choice theory with Drosophila melanogaster shows both sexes can undergo menopause

This study tests the mate choice theory of menopause using Drosophila melanogaster, showing that both sexes can experience fertility decline in old age due to asymmetric mating.

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

Multi-tier mechanics control stromal adaptations in swelling lymph nodes

The paper investigates how lymph nodes accommodate size increases during immune challenges by analyzing biomechanical adaptations of fibroblastic reticular cells and fibroblasts.

Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

The upper respiratory tract microbiome of Australian Aboriginal and Torres Strait Islander children in ear and nose health and disease.

This study examines nasal microbiota in Indigenous Australian children, finding associations between specific bacterial taxa and otitis media status and nose health.

Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer

Performance of generalist hemiparasitic Euphrasia across a phylogenetically diverse host spectrum

This study examines how host species and phylogenetic relationships affect the performance of generalist hemiparasitic plants, finding that performance varies mainly with host traits and some hosts lead to poorer performance over time.

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Ranking the direct threats to biodiversity in sub-Saharan Africa

The paper ranks direct threats to biodiversity in sub-Saharan Africa using expert consensus, IUCN data, and national strategies, identifying agriculture, hunting, and logging as top threats with regional variations.

Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural divergence among human adenoviruses

The paper determines the cryo-EM structure of HAdV-F41, an enteric adenovirus, and compares it to other adenoviruses, revealing structural differences that enhance capsid stability for gut survival.

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.