Cancer BiologybioRxiv
ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97
A. Pozner, S. P. Verma, L. Li…·K. B. Jones
This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.