Author

G. Leon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. M. Rehill· 3 shared J. S. O'Donnell· 3 shared A. Gomez· 2 shared A. Hernandez· 2 shared A. M. Curtis· 2 shared A. Sanchez· 2 shared A. Segura· 2 shared C. Diaz· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

A. M. Rehill

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Trained Immunity Causes Myeloid Cell Hypercoagulability

A. M. Rehill, S. McCluskey, A. E. Ledwith, T. A. Ryan, G. Leon, H. Charles-Messance, E. H. Gilbert, E. A. Day, C. McMahon, J. S. O'Donnell, A. M. Curtis, L. A. O'Neill, F. J. Sheedy, R. J. Preston

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

bioRxiv · Jul 16, 2024Immunology

Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling.

G. Leon, P. A. Klavina, A. M. Rehill, S. Chomanahalli Basavarajappa, J. S. O'Donnell, S. Hussey, P. T. Walsh, R. J. S. Preston

This study identifies TF-mediated thrombogenicity in colitogenic CD4+ T cells and shows APC signalling reduces their procoagulant activity in IBD.

bioRxiv · Apr 16, 2024Immunology

GLYCOLYTIC REPROGRAMMING FUELS MYELOID CELL-DRIVEN HYPERCOAGULABILITY

A. M. Rehill, G. Leon, S. McCluskey, I. Schoen, Y. Hernandez-Santana, S. L. Annett, P. Klavina, T. Robson, A. M. Curtis, T. Renne, S. Hussey, J. S. O'Donnell, P. T. Walsh, R. J. Preston

This study shows inflammation-induced glycolytic reprogramming in myeloid cells drives hypercoagulability and antifibrinolytic activity, with potential therapeutic implications.

bioRxiv · Apr 20, 2023Immunology

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

A. Moreira-Soto, M. Arguedas, H. Brenes, W. Bujan, E. Corrales-Aguilar, C. Diaz, A. Echeverri, M. Flores-Diaz, A. Gomez, A. Hernandez, M. Herrera, G. Leon, R. Macaya, A. Khüne, J. A. Molina-Mora, , J. F. Drexler

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

bioRxiv · Jun 12, 2021 · PreprintMicrobiology

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

G. Leon, M. Herrera, M. Vargas, M. Arguedas, A. Sanchez, A. Segura, A. Gomez, G. Solano, E. Corrales-Aguilar, K. Risner, A. Narayanan, C. Bailey, M. Villalta, A. Hernandez, A. Sanchez, , A. Alape

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

bioRxiv · Oct 17, 2020 · PreprintMicrobiology

Gene expression in isolated cowpea (Vigna unguiculata L. Walp) cells from meiosis to seed initiation

N. R. Gursanscky, D. Mazurkiewicz, M. Juranic, S. D. Johnson, G. Leon, R. Escobar-Guzman, R. Salinas-Gamboa, I. Amasende-Morales, M. Riboni, M. Hand, A. Spriggs, J.-P. Vielle-Calzada, A. M. G. Koltunow

The paper analyzes cell-type transcriptomes from cowpea during meiosis to seed initiation, identifying gene expression patterns related to reproductive development and cell specification.

bioRxiv · Jan 17, 2020 · PreprintPlant Biology