T. A. Ryan

Trained Immunity Causes Myeloid Cell Hypercoagulability

This study identifies enhanced myeloid cell prothrombotic activity as a novel consequence of trained immunity, mediated by epigenetic changes and acid sphingomyelinase.

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

The paper develops a ratiometric ER calcium sensor to enable quantitative comparisons of ER Ca2+ levels across cell types and subcellular regions, showing lower resting Ca2+ in neurons compared to fibroblasts.

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape of Neurodegenerative Disorders

This paper describes a protocol for isolating and lipidomic profiling of neuronal lipid droplets, revealing their unique lipid composition and potential role in neurodegenerative disorders.

iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP

The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.

Joint effects of social interactions and environmental challenges on physiology, internal microbiome, and reproductive performance in tree swallows (Tachycineta bicolor).

The paper manipulates social interactions and ecological challenges in tree swallows to assess their joint effects on physiology, microbiome, and reproductive success, finding limited interaction between the two treatment types.

Developmental stage-dependent effects of perceived predation risk on physiology and fledging success of tree swallows (Tachycineta bicolor)

This study shows that simulated predation during the early nestling period negatively affects tree swallow nestlings' condition, telomere length, and fledging success, with social environment manipulations affecting nestling size but not stress responses.

Within-individual consistency and between-individual variation in the shapes of eggs laid by tree swallows (Tachycineta bicolor)

This study examines egg shape and size variation in tree swallows, finding high individual repeatability and age-related changes, with no link to nestling outcomes.

Plumage manipulation alters the integration of social behavior, physiology, internal microbiome, and fitness.

The paper manipulates plumage in female tree swallows to show that signal variation independently affects social behavior, physiology, microbiome, and reproductive fitness.