Author

M. Larance

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Aggarwal· 2 shared A. Ashhurst· 2 shared F. H. Passam· 2 shared M. Cielesh· 2 shared R. J. Payne· 2 shared S. G. Turville· 2 shared A. Drelich· 1 shared A. E. Brandon· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. Aggarwal

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

K. Wahi, N. Freidman, Q. Wang, M. Devadason, L.-E. Quek, A. Pang, L. Lloyd, M. Larance, F. Zanini, K. Harvey, S. O'Toole, Y. F. Guan, J. Holst

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

bioRxiv · Feb 21, 2024Cancer Biology

Identification of SEC61B as a novel regulator of calcium flux and platelet hyperreactivity in diabetes mellitus

Y. X. Kong, R. Rehan, C. L. Moreno, S. Madsen, Y. Zhang, H. Zhao, S. P. Cartland, C. B. Houlahan, D. Robertshaw, V. Trang, F. J. L. Ong, M. Cielesh, K. C. Cooke, M. Potter, J. Stockli, , F. H. Passam

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

bioRxiv · Feb 20, 2024 · PreprintCell Biology

Hepatic Lipid Droplet-Associated Proteome Changes Distinguish Dietary-Induced Fatty Liver from Insulin Resistance in Male Mice.

A. van Woerkom, D. J. Harney, S. R. Nagarajan, M. F. Hakeem-Sanni, J. Lin, M. Hooke, T. Pulpitel, G. J. Cooney, M. Larance, D. N. Saunders, A. E. Brandon, A. J. Hoy

This study identifies distinct lipid droplet proteome changes in mice fed high-fat or high-starch diets compared to chow, linking these changes to fatty liver and glucose tolerance.

bioRxiv · Mar 9, 2023 · PreprintCell Biology

Ultra-sensitive platelet proteome maps the O-glycosylation landscape and charts the response to thrombin dosage

C. Houlahan, Y. Kong, B. Johnston, M. Cielesh, T. H. Chau, P. Coleman, H. Hao, R. S. Haltiwanger, M. Thaysen-Andersen, F. H. Passam, M. Larance

This paper presents a high-sensitivity proteome analysis of human platelets, identifying O-glycosylation sites and showing that POFUT1 regulates MMRN1 secretion.

bioRxiv · Nov 1, 2022 · PreprintBiochemistry

Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

R. S. Samant, S. Batista, M. Larance, B. Ozer, C. I. Milton, I. Bludau, L. Biggins, S. Andrews, A. Hervieu, H. E. Johnston, B. Al-Lazikhani, A. I. Lamond, P. A. Clarke, P. Workman

This study uses SEC-MS to analyze HSP90 inhibitor effects on protein complexes, identifying both known and novel components of the HSP90-dependent proteome.

bioRxiv · May 23, 2022Biochemistry

Anabolic Factors and Myokines Improve Differentiation of Human Embryonic Stem Cell Derived Skeletal Muscle Cells

T. Ruan, D. Harney, Y. C. Koay, L. Loo, M. Larance, L. Caron

This study enhances the differentiation of human embryonic stem cell-derived skeletal muscle cells using anabolic factors and myokines, improving fusion and muscle marker expression.

bioRxiv · Feb 8, 2022Cell Biology

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

J. Johansen-Leete, S. Ullrich, S. Fry, R. Frkic, M. Bedding, A. Aggarwal, A. Ashhurst, K. Ekanayake, M. Mahawaththa, V. Sasi, T. Passioura, M. Larance, G. Otting, S. G. Turville, C. J. Jackson, , R. J. Payne

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

bioRxiv · Aug 23, 2021Biochemistry

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A. Ashhurst, A. Tang, P. Fajtova, M. Yoon, A. Aggarwal, A. Stoye, M. Larance, L. Beretta, A. Drelich, D. Skinner, L. Li, T. Meek, J. McKerrow, V. Hook, C.-T. Tseng, , R. J. Payne

bioRxiv · Dec 23, 2020 · PreprintBiochemistry