R. J. Payne

This paper develops supramolecular anticoagulants that can be reversed on demand using a PNA antidote, demonstrating potent in vitro and in vivo anticoagulant activity.

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

The paper combines cross-linking mass spectrometry with AI-based structure prediction to discover and validate protein and complex structures at proteome scale.

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

This study identifies resistance mutations in SARS-CoV-2 main protease to the drug Nirmatrelvir using computational screening and experimental validation.

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

This paper introduces a linearization method to detect hidden enzymatic assay interferences by analyzing progress curves in modified coordinates, improving the accuracy of kinetic data selection.