Cancer BiologybioRxiv
Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death
V. Reddy, A. Iskander, C. Hwang…·S.-H. Kim
This study shows that combining an AR antagonist with an ATM inhibitor induces telomere DNA damage and DDR inhibition, leading to cell death in CRPC cells.
DOI 10.1371/journal.pone.0211090