Spatial co-fragmentation pattern of cell-free DNA recapitulates in vivo chromatin organization and identifies tissues-of-origin
Y. Liu, T.-Y. Liu, D. E. Weinberg, B. W. White, C. J. De La Torre, C. L. Tan, A. D. Schmitt, S. Selvaraj, V. Tran, L. C. Laurent, L. Cabel, F.-C. Bidard, G. Putcha, I. S. Haque
The paper shows that fragment length patterns in cell-free DNA reflect in vivo chromatin organization and can identify tissues-of-origin.
bioRxiv · Oct 23, 2019 · PreprintGenomics