Cancer BiologybioRxiv
Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance
P. Simmler, T. Mengis, K. Van-Lehmann…·G. Schwank
This study shows that SF3B1K700E mutation in PDAC enhances tumor aggressiveness when combined with KRAS and p53 mutations by promoting TGF-β resistance.
DOI 10.7554/elife.80683