G. Reyes-Castellanos

This study investigates mitochondrial dysfunction in skeletal muscle of a murine pancreatic cancer-induced cachexia model, identifying metabolic defects beyond traditional pathways.

This study identifies mitochondrial and redox metabolic reprogramming in drug-tolerant persister cells of pancreatic cancer and shows that targeting redox metabolism can prevent relapse.

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.