ImmunologybioRxivPreprint
Tumor-responsive, multifunctional CAR-NK cells cooperate with impaired autophagy to infiltrate and target glioblastoma
J. Wang, S. Torregrosa-Allen, B. D. Elzey…·S. Matosevic
This study develops multifunctional CAR-NK cells that target glioblastoma by addressing antigen escape, poor immune cell homing, and immunometabolic suppression through tumor-specific antibody fragments and autophagy inhibition.
DOI 10.1101/2020.10.07.330043