N. A. Lanman

The target gene regulatory network of miR-497 in angiosarcoma

This study identifies miR-497 as a tumor suppressor in angiosarcoma by regulating target genes like CCND2, CDK6, and VAT1, with VAT1 inhibition reducing tumor migration.

KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development

This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

TNF Blockade Reduces Prostatic Hyperplasia and Inflammation while Limiting BPH Diagnosis in Patients with Autoimmune Disease

Patient data and mouse models suggest that repurposing tumor necrosis factor alpha blockade reduces inflammation-mediated prostatic hyperplasia.

Tumor-responsive, multifunctional CAR-NK cells cooperate with impaired autophagy to infiltrate and target glioblastoma

This study develops multifunctional CAR-NK cells that target glioblastoma by addressing antigen escape, poor immune cell homing, and immunometabolic suppression through tumor-specific antibody fragments and autophagy inhibition.

Integration of Biodynamic Imaging and RNA-seq classifies chemotherapy response in canine diffuse large B-cell lymphoma

This study combines BioDynamic Imaging and RNA-seq data to develop a model predicting chemotherapy response in canine DLBCL by integrating gene expression and phenotypic biomarkers.

Loss of SUV420H2 promotes EGFR inhibitor resistance in NSCLC through upregulation of MET via LINC01510