BioengineeringbioRxiv
Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists
L. Sun, Z.-M. Zheng, C.-S. Shao…·P. Wang
The paper designs long-acting GLP-1 receptor agonists using structural biology to prevent DPP-4 degradation while maintaining receptor binding, achieving hypoglycemic effects lasting over 24 hours.
DOI 10.3390/ph15060740