Author

Gregory Tombline

University of Rochester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrei SeluanoviD· 4 shared Vera A. GorbunovaiD· 4 shared Eric C. Hillpot· 2 shared John C. MartineziD· 2 shared Julia AblaevaiD· 2 shared Victoria PaigeiD· 2 shared Alus M. XiaoliiD· 1 shared Catherine Lan· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMolecular Biology

Andrei SeluanovORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

Jonathan Gigas, Michael E. Meadow, Jing Guo, Catherine Lan, Eric C. Hillpot, John C. Martinez, Gregory Tombline, Philip M. Bellomio, Valeria Rivera-Almodóvar, Kevin A. Welle, Kyle Swovick, Jennifer R. Hryhorenko, Julia Ablaeva, Sina Ghaemmaghami, Andrei Seluanov, Vera A. Gorbunova

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

GeroScience · Jul 8, 2026Peer-reviewedMolecular Biology

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

Seyed Ali Biashad, Eric C. Hillpot, Francesco Morandini, Cheyenne Rechsteiner, Victoria Paige, Gregory Tombline, Minseon Lee, Zhizhong Zheng, Yuan Liang, John C. Martinez, Natasha Sieczkiewicz, Zhihui Zhang, Valentin Pavlovich Volobaev, Denis Firsanov, Matthew A. Simon, , Vera A. Gorbunova

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

bioRxiv · Mar 24, 2025 · PreprintMolecular Biology

Hyaluronidase inhibitor delphinidin inhibits cancer metastasis

Jeremy McGuire, Taketo Taguchi, Gregory Tombline, Victoria Paige, Michelle C. Janelsins, Nikesha J. Gilmore, Andrei Seluanov, Vera A. Gorbunova

This study identifies delphinidin as a hyaluronidase inhibitor that reduces cancer metastasis in cell cultures and mouse models.

Scientific Reports · Jun 28, 2024Peer-reviewedCancer Biology

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

Quanwei Zhang, Gregory Tombline, Julia Ablaeva, Lei Zhang, Xuming Zhou, Zachary Smith, Alus M. Xiaoli, Zhen Wang, Jhih-Rong Lin, Mohammad Reza Jabalameli, Joydeep Mitra, Nha Nguyen, Jan Vijg, Andrei Seluanov, Vadim N. Gladyshev, , Zhengdong D. Zhang

This study identifies genes contributing to beaver longevity and cancer resistance through genomic analysis of gene copy number, expression, and evolutionary changes.

bioRxiv · Jun 25, 2020 · PreprintGenomics