Michael E. Meadow

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

This study uses structural proteomics to show that ubiquitination patterns differ between misfolded nascent proteins and mature proteins, influencing their degradation rates.

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.