Eric C. Hillpot

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.