John C. Martinez

This study shows that STING deficiency in mice increases median lifespan and reduces age-related liver damage.

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.

This study identifies miR-27a as essential for bone remodeling by regulating p62-mediated osteoclast signaling, leading to severe osteoporosis in mice.