Cancer BiologyiSciencePeer-reviewed
The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing
Colin E Fowler, Natalie A. O’Hearn, Griffin J. Salus…·Jacqueline A. Lees
The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.