BiophysicsbioRxivPreprint
Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity
A. D. Stephens, M. Zacharopoulou, R. Moons…·G. S. Kaminski Schierle
This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.
DOI 10.1101/740241