Author

H. Abken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Hombach· 1 shared A. Birt· 1 shared A. Kuenkele· 1 shared A. Pruss· 1 shared B. J. Hackel· 1 shared C. Ambrose· 1 shared C. E. Porter· 1 shared C. Franke· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. A. Hombach

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

J. Kath, C. Franke, V. Drosdek, W. Du, V. Glaser, C. Fuster-Garcia, M. Stein, T. Zittel, S. Schulenberg, C. E. Porter, L. Andersch, A. Kuenkele, J. Alcaniz, J. Hoffmann, H. Abken, , D. L. Wagner

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

bioRxiv · Nov 10, 2023 · PreprintImmunology

CD19-targeting CAR T cells potently redirected to kill solid tumor cells

C. Ambrose, L. Su, L. Wu, F. J. Dufort, T. Stanford, A. Birt, B. J. Hackel, A. A. Hombach, H. Abken, R. R. Lobb, P. D. Rennert

This paper develops CD19-targeting CAR T cells that secrete bridging proteins to enhance tumor targeting and cytotoxicity in solid tumors.

bioRxiv · Mar 25, 2020Cancer Biology