M. Stein

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

Exploring natural genetic variation in photosynthesis-related traits of barley in the field

The paper evaluates photosynthesis-related traits in barley under field conditions, finding heritable variations and correlations with yield traits.

Aalbo1200: global genetic differentiation and variability of the mosquito Aedes albopictus

This study generates whole genome sequencing data from Aedes albopictus populations to analyze genetic differentiation and variability across tropical and temperate regions.

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells

This paper combines CRISPR nucleases to simultaneously knock-in and base edit CAR T cells, reducing translocations to 1.5% and improving safety.

Mex67 paralogs mediate division of labor in trypanosome RNA processing and export.

This study identifies distinct roles for three Mex67 paralogs in trypanosome RNA processing and export, showing non-redundant functions in mRNA export and ribosome biogenesis.

Aedes aegypti and Aedes albopictus abundance, landscape coverage and spectral indices effects in a subtropical city of Argentina

This study examines how landscape coverage and spectral indices affect the abundance of Aedes aegypti and Ae. albopictus in Eldorado, Argentina, using satellite data and statistical models.

Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

This study identifies SPRR1 and SPRR2 as antimicrobial proteins produced by sebocytes that defend the skin by disrupting bacterial membranes, showing increased susceptibility to infections in their absence.

Fast, efficient and virus-free generation of TRAC-replaced CAR T cells

This paper presents a virus-free method to generate CAR T cells by inserting CARs into the TRAC locus using CRISPR-Cas and HDR, achieving up to 68% TCR-to-CAR replacement.

Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies

This study demonstrates the use of electromembrane extraction (EME) combined with mass spectrometry to monitor drug metabolism in liver organoids.

Culex saltanensis and Culex interfor (Diptera: Culicidae) are susceptible and competent to transmit St. Louis encephalitis virus (Flavivirus: Flaviviridae) in central Argentina.

This study shows that Culex saltanensis and Culex interfor can transmit St. Louis encephalitis virus in central Argentina, similar to Culex pipiens quinquefasciatus.

Arabidopsis phytochelatin synthase 1, but not phytochelatin synthesis, functions in extracellular defense against multiple fungal pathogens

This study identifies PCS1 as a moonlighting protein involved in extracellular defense against fungal pathogens in Arabidopsis, independent of its known role in heavy metal detoxification.

MroQ is a Novel Abi-domain Protein That Influences Virulence Gene Expression in Staphylococcus aureus via Modulation of Agr Activity

This paper identifies MroQ as a novel Abi-domain protein in S. aureus that modulates Agr activity, affecting virulence gene expression and pathogenic outcomes.

R51Q SNX10 induces osteopetrosis by promoting uncontrolled fusion of monocytes to form giant, non-functional osteoclasts

This study identifies R51Q SNX10 mutation as a cause of osteopetrosis by promoting abnormal monocyte fusion into non-functional giant osteoclasts.